Latest Marrone biologics company goes after invasive golden mussel infestation

Abstract

Publication: Sacramento Business Journal

Invasive Species Corp., a Davis-based biological controls company founded by industry pioneer Pam Marrone, is adapting its patented mussel control product Zequanox to target the newly discovered golden mussel infestation in California. First detected in the Port of Stockton in October 2024, golden mussels have since spread to over 40 sites across the Sacramento Delta and Central Valley, threatening sensitive ecosystems, infrastructure, and water quality. Zequanox, originally developed to control zebra and quagga mussels, uses a naturally derived, selective bacterium that kills invasive dreissena mussels without harming native species or fish.

Approved by the EPA for enclosed and open systems, Zequanox offers an environmentally safer alternative to copper and chlorine treatments. Marrone’s new company plans to refine application techniques and dosage for golden mussels through laboratory testing in Davis. With a background that includes founding multiple successful biologics companies—one sold to Bayer for $500 million and another acquired after IPO for $236 million—Marrone launched Invasive Species Corp. in 2022 following a non-compete period. The startup has also raised $2.5 million in pre-seed funding and is exploring solutions for other invasive aquatic species such as Asian carp and burrowing shrimp.